Effect of Ethanolic Extract of Semecarpus Anacardium Fruit on Carrageenan Induced Paw Edema in Albino Rats

Background: Semecarpus anacardium plant derivatives has been used since antiquity, The fruit and nut extract of Semecarpus anacardium shows various activities like antiatherogenic, anti-inflammatory, antioxidant, antimicrobial, antireproductive, CNS stimulant, hypoglycemic, anticarcinogenic. The present study is an attempt to explore the anti-inflammatory activity of ethanolic extract of fruits of Semecarpus. anacardium plant in albino rats by employing carrageenan induced rat hind paw edema model . Methods: Acute antiinflammatory model performed on wistar male albino rats (150-200gm) were divided into 4 groups, each group containing 6 albino rats, group 1 serving as control, group 2 as standard, group 3 receiving 300mg/kg.b.wt of ethanolic extract of Semecarpus anacardium fruit and group 4 receiving 600 mg/kg.b.wt of ethanolic extract of Semecarpus anacardium fruit. The anti-inflammatory property was assessed by Plethysmograph. Results: Ethanolic extract of Semecarpus anacardium fruit demonstrated a significant anti-inflammatory property at different levels when compared to control and standard (p< 0.05). Conclusion: Ethanolic extract of Semecarpus anacardium fruit exhibited a dose dependent anti-inflammatory activity in carrageenan induced rat paw edema model of inflammation and shows that this is a potent source of phytomedicine development in the future.